* Administration
* Finance & Accounts
* Planning, Research & Statistics
* Medical Services
* Pharmaceutical services
* Public Health services
* Nursing services
* Special duties
* Rivers State Hospitals Management Board
* Rivers State Primary Health Care Management Board
* Rivers State School of Nursing
* Rivers State School of Midwifery
* Rivers State Agencies for control of Aids (RIVSACA)
* Rivers State University Teaching Hospital
* Formulate Health Policies, Plans and Programmes
* Advise Government on Health Matters
* Train Health Personnel
* Supervise Hospitals Management Board
* Implement National Health Programmes
* Promote and protect individual and community health through the enforcement of Public Health laws.
* Enforce pharmacy laws and control pharmaceutical services
* Purchase and distributes drugs and medicaments.
* Provide primary health care services with the active participation of Local Government Councils.
* Collect, collate and publish medical and other health statistics.
* Supervise training institutions viz: the schools of Nursing & Midwifery, Port Harcourt,
* Coordinate, standardize, register and supervise Public and Private Health Institutions, Health oriented NGOs and international Development Agencies.
* Provide Public Enlightenment on health issues
* Procure, distribute & install Medical Equipment
* Implement special programmes, namely Emergency Medical Services, HIV/AIDS, Roll Back Malaria. etc